PDCD1 and non-small cell lung carcinoma: The nonsynonymous mutational load and predicted class-I neoantigen content in our study were similar to a previous report including 34 advanced NSCLC cases treated with PD-1 blocking antibodies (median of 256 vs 200 nonsynonymous mutations per genome; and 72 vs 112 candidate class-I neoantigens per tumor13).