PRF1 and lung adenocarcinoma: As shown in Supplementary Figure 9, the mutational load was only marginally correlated with the level of adaptive immunity transcripts in lung adenocarcinomas including CD8A, CXCL10, GZMB, IFNG, and STAT1 (Spearman’s R = 0.14–0.3) and there was no relationship with other TIL markers such as CD3, CD4, PRF1 and MS4A1 (Spearman’s R = −0.08–0.006, Supplementary Figure 9A).