Both the physical interactions between Notch3 and β-catenin revealed by co-immunoprecipitation and co-localization in vitro and the upregulation of Notch3 and β-catenin levels in patient tumor samples after acquiring resistance to EGFR TKI suggests that it may be direct association between Notch3 and β-catenin proteins that is responsible for the activation of β-catenin. Here, NOTCH3 is linked to neoplasm.