We showed that (1) a transient elevation of IOP by MB injection is sufficient to induce T-cell infiltration into the retina and a prolonged phase of retinal neurodegeneration, (2) T cells are required for mediating the prolonged retinal neurodegeneration and are specific for HSPs, and (3) induction of HSP-specific T cells and glaucomatous retinal neurodegeneration by elevated IOP require exposure to commensal microflora. This evidence concerns the gene HSP90B2P and neurodegenerative disease.