For instance, the mitotic checkpoint protein BUB3 and dolichol‐phosphate mannosyltransferase subunit (DPM1) were stronger dependencies in HNSCC, while the adenylosuccinate lyase (ADSL), the cytochrome b‐c1 complex subunit 1 (UQCRC1) and the NADH dehydrogenase 1 beta subcomplex subunit 4 (NDUFB4) belonged to a subset of proteins that reflected stronger dependencies in SQCLC. This evidence concerns the gene ADSL and head and neck squamous cell carcinoma.