Specifically, these clinical features, as indicated by hyperpyrexia, sputum-coughing, persistent elevated IgE and eosinophils in the blood, eosinophil infiltration in the bronchus, positive BAL-G assay (G assay of BAL), and T-spot negativity as well as the failure to reveal acid-fast bacilli, led to possible infection with a pulmonary fungus. The gene discussed is IGHE; the disease is infection.