In conclusion, our results clearly demonstrated that eight weeks of HFD diet feeding in SD rats induced a significant dysfunction in adipose tissues among NAFLD rats, shown by the major reduction in adiponectin, and the considerable increase in vaspin, progranulin, RBP4, IL-6, and TNFα, leading to upregulation of PPARγ, SLC10A2, and Coll α1 genes, which are all involved in insulin resistance, hepatic steatosis, and fibrosis. This evidence concerns the gene SLC10A2 and Insulin resistance.