A recent study by Gao et al. has proposed that the pathological changes in circulating levels of adipocytokines during NAFLD progression are linked with the expansion of adipose tissues, concomitantly with a release of extracellular vesicles from adipocytes, which is involved in stimulating insulin resistance and augmenting growth factor β expression, inflammation, and fibrosis in the liver [65]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.