INS and metabolic dysfunction-associated steatotic liver disease: Moreover, the beneficial effects of 50% ME of P. niruri against NAFLD progression may be also due to its potent antiangiogenic effect, which is responsible for attenuating the pathological expansion of adipose tissues and regulating its function, leading to the adjustment of adipocytokine secretion, improvement in insulin signaling, and prevention of inflammation and fibrosis in the liver.