Despite our earlier encouraging data, which confirmed that a standardized 50% methanolic extract (50% ME) of P. niruri inhibited the progression of NAFLD in Sprague–Dawley (SD) rats, reduced NAFLD activity score (NAS), prevented fibrosis, and improved serum levels of liver enzymes, glucose, insulin, insulin resistance, lipid profile, serum free fatty acids (FFAs), and hepatic contents of total cholesterol and triglyceride [14], to date, the pathways underling the molecular mechanism of action have not yet been elucidated. The gene discussed is INS; the disease is fibrosis.