PTEN and endometrial carcinoma: The estrogen-dependency of EC tumors was examined in PTEN deleted mice, leading to the conclusion that EC tumorigenesis is independent of estrogen in PTEN+/− mice [115] and the depletion of estrogen predominantly leads to neoplastic lesions, possibly explaining why endometrial carcinoma incidence is higher in peri- and postmenopausal women [116].