Remarkably, this association did not change (HR 0.37 (95% CI 0.14–0.99), p = 0.047) after additional adjustment for common confounders of cardiovascular disease as of ((log) troponin), surrogate of systolic heart function ((log) NT-pro BNP), and anaemia ((log) hemoglobin). The gene discussed is NPPB; the disease is anemia (phenotype).