CD40LG and nasopharyngeal carcinoma: For example, the polysaccharides from Sargassum fusiform significantly inhibited the growth of nasopharyngeal carcinoma cell line (CNE) by increasing serum cytokines and IgM levels in CNE-bearing mice and stimulated the secretion of cytokines from peritoneal macrophages, which stimulated the proliferation of splenic lymphocytes and increased the expression of IgM in splenic lymphocytes [162].