PTEN and acute myeloid leukemia: In AML cells, METTL3 and METTL14 bound predominantly to transcription start sites, even if METTL3 binding did not always correlate with METTL14, and early m6A co-transcriptional deposition promoted translation of mRNAs relevant for AML proliferation, such as c-MYC, BCL2, PTEN, SP1 and MYB [51,52,53].