Notably, AML is one of the cancers with the highest levels of both METTL3 and METTL14 expression (data from the Cancer Genome Atlas, TCGA) and, more importantly, METTL3 and METTL14 were found overexpressed in AML cells compared to normal haematopoietic progenitors [51,52,53,54]. The gene discussed is METTL3; the disease is cancer.