Furthermore, studies in vitro in MM cell lines, conducted by Besses et al. revealed that tinostamustine, is a potent ER stress-inducing, HDAC6-inhibiting, immunomodulatory, cell cycle inhibiting, pro-apoptotic, and c-MYC-antagonistic activity, in contrast to vorinostat or bendamustine [174]. The gene discussed is HDAC6; the disease is Miyoshi myopathy.