Yang et al. conducted a study in leukemia patients observing a significant overexpression of HDACs in CLL patients, with heterogeneous expression of HDACs in myeloid malignancies, such as acute myeloid leukemia and myelodysplastic syndromes, without a leukemia-specific HDAC gene expression profiles [68]. Here, HDAC9 is linked to B-cell chronic lymphocytic leukemia.