IFNB1 and infection: To this aim, we deleted the VACV C6L gene in MVA-HCV, coding for an inhibitor of IFN-β, and performed a head-to-head comparison between MVA-HCV and MVA-HCV ΔC6L, analyzing the expression of HCV proteins and evaluating, by real-time polymerase chain reaction (PCR) and microarrays, the profile of host gene expression induced after infection of human moDCs or macrophages.