Deletion of VACV C6L gene in the HIV/AIDS vaccine candidate MVA-B enhanced HIV-1-specific cellular and humoral immune responses in mice in comparison with the parental MVA-B vector without deletions, and induced the expression of type I IFN and IFN-α/β inducible genes in human macrophages and monocyte-derived dendritic cells (moDCs) [22,24]. Here, IFNA1 is linked to AIDS.