Rat colon tumors exposed to sulindac and naproxen individually or in combination with atorvastatin showed significant suppression of PCNA, cyclin D1 and β-catenin and reduced key inflammatory markers, inducible NOS and COX-2, p65, as well as inflammatory cytokines, TNF-α, IL-1β, and IL-4 [68]. The gene discussed is NOS2; the disease is colonic neoplasm.