Upon DTMUV infection, key PRRs (RIG-I and MDA5) in the immune system were activated, inducing increased production of cytokines (IFN-α2, IL-6, IL-8L, IL-12B, CCR7, CCL19, and CCL20), transcription factors or signaling molecules (IRF7, NF-κB, STAT1, TMEM173/STING and TNFAIP3), and antigen-presenting proteins (CD44 and CD70). Here, IFIH1 is linked to infection.