Further research should examine the mechanistic requirement for Pax2 loss in HGSC progression, especially considering that there is increased hypomethylation and activation of Pax2 in endometrial and renal carcinoma, yet The Cancer Genome Atlas (TCGA) does not find increased methylation at this locus in HGSC tumor samples [47,62,63]. Here, PAX2 is linked to neoplasm.