Besides, one study investigated the roles of miR-34 and Rho GTPases in cancer cells; Huang et al. demonstrated that two key mechanisms involved in cancer metastasis—epithelial-to-mesenchymal transition and mesenchymal-to-amoeboid transition—were coupled through two miRNAs, namely miR-200 and miR-34, both of which inhibited RhoA and Rac1 [46]. Here, RAC1 is linked to cancer.