ATG5 and infection: In a study conducted on Ae. aegypti mosquitoes, it was seen that upon DENV2 infection, Autophagy-related 5 (ATG5) transcript levels were elevated in the midguts of DENV2-susceptible mosquito strains in comparison to refractory strains, and this increase was found to coincide with the increase in the expression of genes involved in apoptosis [163].