CD40 and obesity due to melanocortin 4 receptor deficiency: In line with the phenotype of the CD40flflLysMcre mice, hematopoietic disruption of CD40 did decrease adipose tissue T-cell accumulation but did not affect obesity-induced insulin resistance in mice [24], indicating that non-hematopoietic cell CD40 expression probably contributes to the phenotype observed in the total body CD40 knock out mice.