In line with the phenotype of the CD40flflLysMcre mice, hematopoietic disruption of CD40 did decrease adipose tissue T-cell accumulation but did not affect obesity-induced insulin resistance in mice [24], indicating that non-hematopoietic cell CD40 expression probably contributes to the phenotype observed in the total body CD40 knock out mice. The gene discussed is CD40; the disease is Insulin resistance.