miR-146a-5p expression is reportedly upregulated by TNF-α stimulation in vitro [23, 66] and increases in synovial tissue [66], synovial fibroblasts [23], CD4+ T-cells [67], PBMCs [68], synovial fluid [22], and plasma [22] in RA patients compared with healthy controls. The gene discussed is CD4; the disease is rheumatoid arthritis.