Among 64 African-American children (5-6y), there was a weak association between lower BMI percentiles and higher saliva methylation in DNMT3B, but no relationships with other obesity-related genes (FTO, MAOA, SH2B1, LEPR, BDNF or CCKAR) [54]. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.