GPT and major depressive disorder: They considered that depression symptoms were usually associated with poor appetite and poor nutrition in hemodialysis patients with depression.[72] Another study by Peng et al[73] showed that biochemical parameters, such as urea nitrogen, alanine transaminase, uric acid, lactate dehydrogenase, and total protein, were significantly different between depression patients and healthy controls, and that multiple biochemical parameters in combination may improve the diagnostic effectiveness of depression and the complete management for depressive patients.