One study showed that antidepressant treatment has increased serum albumin and blood urea nitrogen level;[79] the other study showed serum albumin concentration did not change significantly before and after antidepressant treatment.[95] This may suggest that in our study, depression per se and not antidepressant drug is associated with the change of biochemical indicators because appetite-related biochemical indicators did not increase or remained unchanged, but decreased instead. This evidence concerns the gene ALB and major depressive disorder.