We identified twelve important features relevant to depression: body temperature, glucose, creatine kinase, albumin, hydroxybutyrate dehydrogenase, blood urea nitrogen, uric acid, creatinine, cholesterol, total protein, pulse, and respiration, which differentiate patients with comorbidity of hypertension and depression from patients with hypertension at 73.5% overall classification accuracy. Here, ALB is linked to depressive symptom measurement.