CRP and major depressive disorder: More recently, a longitudinal big data analysis of 35,488 patients found that body temperature can predict mortality because inflammation may lead to a higher temperature.[33] To date, existing literature suggests that inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-1 (IL-1) are positively associated with depression.[34] Nevertheless, further research is needed because these factors were not examined in the present study.