The previous studies conducted by Singh et al and Jonsson et al showed low serum albumin levels have been associated with malnutrition.[92,93] BMI is one of the parameters used to estimate nutritional status, and BMI < 20.5 kg/m2 is a risk cutoff for malnutrition.[94] We reviewed the studies by Wang et al and Peng et al, and found that BMI was mentioned in the 2 studies.[61,73] However, BMI did not differ significantly between patients with depression and those without groups in patients with chronic renal failure undergoing hemodialysis and between depressed patients and the control groups. This evidence concerns the gene ALB and major depressive disorder.