ZEB2 and cancer: The pooled analysis of studies demonstrated that, for miR-200 family, the improved OS existed only for enhanced expression of miR-200c, which accords with the results by Shi.[11] MiR-200 family members have been reported to regulate EMT by targeting ZEB1 and ZEB2, resulting in dysregulation of the cell–cell adhesion molecule E-cadherin.[33,34] E-cadherin downregulation is clearly important in cancer progression, facilitating cell detachment and metastasis.