Furthermore, miR-200 family members target EMT regulators, apparently being important in tumor progression.[29] Studies also found that cells expressing miR-200c played an important role in restoring expression of E-cadherin and altering morphology from mesenchymal to epithelial.[35] Similarly, the pooled analysis of studies demonstrated that, for miR-200 family, the improved PFS existed for elevated expression of miR-200a and miR-141. This evidence concerns the gene CDH1 and neoplasm.