BRCA2 and ovarian cancer: Recent advances in understanding the causes of ovarian cancer suggest that many high-grade serous cancers (HGSCs) originate from the epithelium of the FT.22–24 Identification of HGSC in BRCA1 and BRCA2 carriers led to risk-reducing bilateral salpingo-oophorectomy and very careful pathological examination of the FT that identified “serous tubal intraepithelial carcinoma” (STIC) as the early-stage precursor of these cancers.22 Newly developed genetically engineered mouse models for ovarian cancer have confirmed the site of origin in the FT and subsequent progression from STIC to HGSC.