Recent advances in understanding the causes of ovarian cancer suggest that many high-grade serous cancers (HGSCs) originate from the epithelium of the FT.22–24 Identification of HGSC in BRCA1 and BRCA2 carriers led to risk-reducing bilateral salpingo-oophorectomy and very careful pathological examination of the FT that identified “serous tubal intraepithelial carcinoma” (STIC) as the early-stage precursor of these cancers.22 Newly developed genetically engineered mouse models for ovarian cancer have confirmed the site of origin in the FT and subsequent progression from STIC to HGSC. The gene discussed is BRCA1; the disease is ovarian cancer.