TP53 and ovarian cancer: Recent advances in understanding the pathogenesis of ovarian cancer suggest that many HGSC originate from the FT fimbriae, and that STIC represents the putative precursor of these neoplasms.22–24 Evidence for this hypothesis is the observation that nearly all STIC contain p53 mutations similar to HGSC.23 We observed that primary cilia incidence was decreased on secretory cells in STIC lesions in both humans and a mouse model, but abundant in surrounding normal mucosal tissue.