DLX3 and tricho-dento-osseous syndrome: Haploinsufficiency has also been discussed by Nieminen et al. (2011) as a cause for the phenotypic features seen in individuals with the c.571_574delGGGG variant, suggesting the syndromic features of TDO are simply a result of too little wild‐type DLX3 and, as such, a reduction in DLX3 activity.