Previous studies disclosed that mTOR‐STAT3‐HK2 pathway is involved in the glycolysis of hepatocellular carcinoma (HCC) cells and STAT3 may regulate HCC glycolysis through HK2 pathway.37 Moreover, our results showed that STAT3 might directly suppress the promoter activity of SIRT3. This evidence concerns the gene SIRT3 and hepatocellular carcinoma.