SIRT3 and cancer: SIRT3 is one of the sirtuins of NAD‐dependent deacetylases and located in mitochondria.25 SIRT3 is involved in the processes of energy metabolism and development of diseases including the cancer, cardiovascular, and nervous systems.26, 27, 28 SIRT3 adjusts several mitochondrial functions,29, 30 such as managing ROS, ATP production, and cell death.