We found that monocytes from advanced PCa/mCRPC (PCa‐M) secreted significantly higher levels of IL‐1β and chitinase‐3‐like 1 (CHI3L1) compared with monocytes from those with stable disease (PCa‐N) which narrowed our focus to these two prospective proteins. The gene discussed is IL1B; the disease is posterior cortical atrophy.