Previous research has described an IL1‐IL1R‐dependent mechanism as being essential in shaping the tumor‐promoting phenotype of monocytes and macrophages.6 Additionally, macrophage‐derived IL‐1β has been shown to influence the growth and regulation of androgen receptor (AR) and PSA levels in androgen‐responsive prostatic epithelial cells (LNCaP).7 The expression of CHI3L1 has been associated with a poor prognosis in PCa. This evidence concerns the gene IL1R1 and posterior cortical atrophy.