Several studies have reported that elevated hs‐CRP and Lp‐PLA2 concentrations are significantly associated with atherosclerosis characterized by artery plaques and artery stenosis.18, 19 Significant associations have also been found between CRP combined with Lp‐PLA2 and atherosclerotic events, such as coronary heart disease and stroke.7, 20 An elevated Lp‐PLA2 level was shown to be significantly associated with carotid artery plaques, but this association became non‐significant when Mendelian randomization methods were adopted.21 This evidence concerns the gene CRP and atherosclerosis.