In those patients with more severe pancreatic disease, endogenous insulin secretion assessed by the UCP:Cr ratio was lower than in those without diabetes [median UCP:Cr ratio 1.1 nmol/mmol (IQR 0.6–1.5) compared to 2.1 nmol/mmol (1.4–5.6), respectively; P  =  0.04]. The gene discussed is INS; the disease is pancreas disorder.