SIRT1 and breast cancer: SIRT1 gene silencing has caused a significant increase of global expression levels of the 3 targeted epi-marks in all transfected lines versus non-transfected control lines, we thus concluded that SIRT1 is actively responsible for the modulation of H3k4ac, H3k9ac, and H4k16ac in luminal and triple-negative molecular subtypes of breast cancer.