Moreover, SIRT1 deficiency is associated with substantial induction of acetylated H3k4 and H3k9 epigenetic marks on 6 breast cancer-related gene promoters: AR, BRCA1, ERS1, ERS2, EZH2, and EP300. We postulate that SIRT1 plays a differential role in breast cancer development depending on molecular subtype, in part through its epigenetic action. The gene discussed is AR; the disease is breast cancer.