SIRT1 and breast carcinoma: In this study, we examined for the first time the epigenetic mechanisms by which SIRT1 regulates the acetylation patterns of histones H3 and H4 epigenetic marks in sporadic breast cancer, we also investigated the link between SIRT1 and the 3 epi-marks H3K4ac, H3K9ac and H4K16ac in all 5 intrinsic subtypes of the disease.