ESR1 and breast carcinoma: The targeted genes are strongly deregulated and directly implicated in the pathogenesis of breast cancer, as follows: ERS1, ERS2 and AR genes that code for the Estrogen receptors (ER-α), (ER-β) and the Androgen receptor (AR) respectively, the tumor suppressor gene BRCA1, and EZH2 and EP300 genes coding for histone modifying enzymes (EZH2) and (p300) respectively.