The targeted genes are strongly deregulated and directly implicated in the pathogenesis of breast cancer, as follows: ERS1, ERS2 and AR genes that code for the Estrogen receptors (ER-α), (ER-β) and the Androgen receptor (AR) respectively, the tumor suppressor gene BRCA1, and EZH2 and EP300 genes coding for histone modifying enzymes (EZH2) and (p300) respectively. This evidence concerns the gene ESR2 and breast cancer.