SIRT1 and breast neoplasm: After uncovering an inverse correlation between SIRT1 and H3k4ac expression patterns, a simultaneous co-occupancy on the same genomic locus and a direct physical interaction between the two across all breast tumors subtypes, we hypothesized that HDAC SIRT1 could play an active role in the deacetylation of H3k4ac in human breast cancer.