After uncovering an inverse correlation between SIRT1 and H3k4ac expression patterns, a simultaneous co-occupancy on the same genomic locus and a direct physical interaction between the two across all breast tumors subtypes, we hypothesized that HDAC SIRT1 could play an active role in the deacetylation of H3k4ac in human breast cancer. This evidence concerns the gene SIRT1 and breast carcinoma.