The post-hoc analysis distinguished 3 distinct patterns of SIRT1 enrichment depending on human breast tumors subtypes, SIRT1 was found to be most enriched on target gene promoters in luminal B subtypes, then luminal A and HER2-enriched subtypes and finally, least enriched in TNBC subtype (Figure 3A). Here, ERBB2 is linked to breast neoplasm.