A large meta-analysis of genetic variants associated with colorectal cancer derived an aggregate relative risk of 1.17 (95% CI 1.01–1.34) for monoallelic mutations in MUTYH, less than the relative risk of having a first-degree relative with colorectal cancer (RR 2.25, 95% CI 2.00-2.53) [15]. This evidence concerns the gene MUTYH and colorectal cancer.