Therefore, the combined effect of the upregulation of EGFR and/or PAR2 and/or COX2 showed higher prognostic value than each of the isolated genes in the clinical outcome, reinforcing the presence of a positive crosstalk between PAR2 and the EGFR signaling pathway, which mediates COX2 induction, chemoresistance and worse survival in the cervical cancer model. This evidence concerns the gene PTGS2 and cervical cancer.