PTGS2 and cervical carcinoma: Therefore, the combined effect of the upregulation of EGFR and/or PAR2 and/or COX2 showed higher prognostic value than each of the isolated genes in the clinical outcome, reinforcing the presence of a positive crosstalk between PAR2 and the EGFR signaling pathway, which mediates COX2 induction, chemoresistance and worse survival in the cervical cancer model.