The patients with small tumor size (P = 0.024), high nuclear grade (P = 0.0038), negative ER and PgR status (P ≤ 0.0001), positive HER2 status (P = 0.032) and subtype (HER2-enriched, triple-negative; P ≤ 0.0001) were more likely to achieve pCR. Here, ESR1 is linked to neoplasm.