Some complex interaction between genotype and phenotype have been published, for example, the TKCR syndrome (Torticollis, keloids, cryptorchidism, and renal dysplasia), which is caused by deletion of Xq28 (72) coincides with genomic coordinates of a BRCC3 gene. Here, BRCC3 is linked to torticollis-keloids-cryptorchidism-renal dysplasia syndrome.