PTPN11 and Noonan syndrome with multiple lentigines: For example, LEOPARD syndrome and Noonan syndrome, belonging to RASopathies, share several phenotypic features: characteristic facies, congenital heart defects, delayed development, and cryptorchidism for which the molecular causes are heterozygous mutations in various exons of RAF1 and PTPN11 (26, 40, 49).