RHO and retinitis pigmentosa 1: ATF4 overexpression contributed to the photoreceptor cell loss, therefore the deletion of ATF4 in a rhodopsin mice model enhanced photoreceptor survival that was accompanied by an increase of autophagy (Bhootada et al., 2016) hence there is a therapeutic potential in controlling ATF4 expression in RP (Pitale et al., 2017).