In the general population, clinical evidence suggests an increased tendency for pro-inflammatory markers in persons with depression (increased interleukin [IL]-6, TNF-α, and CRP) relative to controls (Laske et al., 2008; Steiner et al., 2012), a trend that normalizes following response to antidepressants (Myint et al., 2005). This evidence concerns the gene CRP and major depressive disorder.