From such an aspect, our findings that FOG2 and GATA3 differentially regulate EMT-related gene expressions suggest that both EMT-dependent and –independent pathways may collectively contribute to lung cancer metastasis, and GATA3 may act as a master regulator of both EMT-dependent and –independent metastasis and serve as a convergence point for the crosstalks between EMT-dependent and –independent pathways. The gene discussed is ZFPM2; the disease is lung cancer.