DEPDC5 and Sudden unexpected death in epilepsy: Eight SUDEP cases belonged to seven families with multiple affected members in which a pathogenic null variant was identified in DEPDC5 (two SUDEP cases were in the same family) and one carried a pathogenic loss-of-function (LoF) variant in NPRL3 segregating in a large autosomal dominant SHE family (pedigrees are shown in Fig. S1).