This suggests that immunopathologies, such as Cryopyrin-associated periodic syndromes (CAPS), that lead to exaggerated levels of IL-1β are unlikely to cause aberrant production of effector cytokines by memory CD4 T cells, since TCR ligation and co-stimulation are necessary to elicit memory CD4 T cell functions. The gene discussed is CD4; the disease is cryopyrin-associated periodic syndrome.