We screened the prevalence of USP48 and BRAF mutations in additional 69 corticotroph adenomas with wild-type USP8. We found that 18.8% of these cases (13/69) had BRAF V600E mutations and 21.7% of these cases (15/69) harbored USP48 mutations. Here, USP8 is linked to ACTH-producing pituitary gland adenoma.