AKT1 and colorectal cancer: The Abd-7 compound inhibits phosphorylation of both downstream biomarkers (Fig. 4a, b) in colorectal cancer (DLD-1, KRASG13D) and non-small cell lung cancer (H538, KRASG12C) human cell lines in a dose dependent way, with reduction of AKT phosphorylation starting at 2 μM.