Notably, the cooperative ability of ATO and ATRA to eliminate TICs in TNBC by targeting Pin1 is consistent with the previous findings that genetic or chemical inhibition of Pin1 induces PML/RARα degradation to eradicate leukemia stem cells and treat APL without inducing myeloid differentiation20,21,24. The gene discussed is PIN1; the disease is acute promyelocytic leukemia.