Notably, ATRA also induced AQP9 expression and cooperated with ATO to induce Pin1 degradation, destabilization of Pin1’s substrate oncoproteins, and stabilization of Pin1’s substrate tumor suppressors, in both TNBC cell orthotopic and PDOX tumors (Fig. 5o and Supplementary Fig. 6f). The gene discussed is PIN1; the disease is neoplasm.