Notably, the cooperative ability of ATO and ATRA to eliminate TICs in TNBC by targeting Pin1 is consistent with the previous findings that genetic or chemical inhibition of Pin1 induces PML/RARα degradation to eradicate leukemia stem cells and treat APL without inducing myeloid differentiation20,21,24. This evidence concerns the gene RARA and acute promyelocytic leukemia.