LDHA and neoplasm: Cells that were subjected to chronic miR-34a that were either proliferation-arrested (SUM-34a_PA) or proliferation-recovered (SUM-34a_PR) showed features of having a reduced BCSC pool, as revealed by: (i) the significant reduction of positive cells for ALDH staining, which marks the stem cell pool [39] (Fig. 6h), (ii) the decrease in SFE in the mammosphere assay (Fig. 6i and Supplementary Fig. 6d–e), and (iii) the decrease in tumour-initiating cell (TIC) frequency measured by xenotransplantation experiments at limiting dilution (Fig. 6j).