To investigate the expression of OGT and OGA in human CRC tissues, we reviewed the Cancer Genome Atlas (TCGA) by the Oncomine database and found that the OGT mRNA level was significantly elevated in all types of CRC, including cecum adenocarcinoma, colon adenocarcinoma, colon mucinous adenocarcinoma, rectal adenocarcinoma, and rectal mucinous adenocarcinoma, compared with that in normal colorectal tissues (Fig. 1d). Here, OGA is linked to rectum mucinous adenocarcinoma.