OGT and malignant colon neoplasm: Meanwhile, the xenograft model also revealed that the number of metastatic nodules in the liver and lung was dramatically decreased when O-GlcNAcylation was downregulated in the SW620 cells but increased when OGT and O-GlcNAcylation were upregulated in the SW480 cells (Fig. 2j, k), indicating that O-GlcNAcylation promotes the metastatic capacity of colon cancer cells in vivo.