NF1 and neoplasm: Notably, the highly significant eQTL associations between ccrSNPs and expression of SH2B3 (linear regression P ≥ 5.62 × 10−20) and NF1 (P ≥ 1.32 × 10−56) in blood revealed risk alleles to be associated with decreased gene expression for both loci, consistent with the role of these genes in tumor development.