APP and Alzheimer disease: Furthermore, NE was shown to suppress microglial inflammation and increase phagocytosis of synthetic Aβ42 fibrils in cell culture, while NE deficiency in APP transgenic mice enhanced brain tissue cytokine levels and exacerbated AD‐like cytopathology (Heneka et al, 2002, 2006, 2010; Kalinin et al, 2007; Kong et al, 2010).