Healthy subjects were younger, but in logistic regression models including age and gender, CXCL10 and CXCL13 remained significantly associated with the presence of SLE (OR 1.18 (1.06, 1.31), p = 0.002 and OR 1.01 (1.00, 1.01), p = 0.016). Here, CXCL10 is linked to systemic lupus erythematosus.