Associations between insulin therapy and MD were not very different in analyses comparing insulin-treated T2D patients with T2D patients receiving noninsulin glucose-lowering medication; that is, insulin-treated T2D patients had a greater percent and absolute dense volume and a smaller absolute nondense volume than non-insulin-treated T2D patients, with the absolute dense volume association being specific for insulin glargine use (Additional file 1: Table S6). The gene discussed is INS; the disease is type 2 diabetes mellitus.