The top 10 genes of the MCODE score included AURKA, AURKB, CDCA8, and MCM4. Among these, CDCA8 (cell division cycle associated 8) activated AURKB (Aurora B kinase) and played an important role in liver regeneration and development of tumor, and might be a potential target for related liver diseases [48]. Here, MCM4 is linked to neoplasm.