KDM5B and neoplasm: Consistent with this, result of our cell cycle analysis showed that depletion of JARID1B not only inhibited H441 cell proliferation via enhanced cell death, but also had an uncoupling effect on the NSCLC cell cycle progression as demonstrated by the shJARID1B-induced significant reduction in the population of cells in G0/G1 and S-phases, while increasing the number of cells in G2/M phase, which is indicative of reduced tumor cell growth and DNA replication, coupled with enhanced DNA damage (Additional file 3: Figure S3).