HLA-DRB1 and rheumatoid arthritis: In the subset-analyses of patients with RA who were smokers and who carried the HLA-DRB1 SE allele (n = 266), compared to controls who were also smokers and carried the HLA-DRB1 SE allele (n = 121) (Table 3), a high score was associated with a 37% lower odds of developing RA, although this was not statistically significant (adjOR = 0.63, 95% CI 0.28–1.37).